Research Areas

Brainstem Circuit Architecture

  • Molecular ontology of the parabrachial nucleus

    Samyukta Karthik, Dake Huang, Yaritza Delgado, Justin J. Laing, Lila Peltekian, Gabrielle N. Iverson, Fillan Grady, Rebecca L. Miller, Corey M. McCann, Bernd Fritzsch, Igor Y. Iskusnykh, Victor V. Chizhikov, JC Geerling

    Journal of Comparative Neurology 530 (10), 1658-1699

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  • Direct parabrachial–cortical connectivity

    F Grady, L Peltekian, G Iverson, JC Geerling

    Cerebral Cortex 30 (9), 4811-4833

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  • Efferent projections of Nps‐expressing neurons in the parabrachial region

    R Zhang, D Huang, S Gasparini, JC Geerling

    Journal of Comparative Neurology 532 (6), e25629

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  • Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice

    D Huang, FS Grady, L Peltekian, JC Geerling

    Journal of Comparative Neurology 529 (4), 657-693

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  • Efferent projections of CGRP/Calca‐expressing parabrachial neurons in mice

    D Huang, FS Grady, L Peltekian, JJ Laing, JC Geerling

    Journal of Comparative Neurology 529 (11), 2911-2957

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  • BoutonNet: an automatic method to detect anterogradely labeled presynaptic boutons in brain tissue sections

    FS Grady, SA Graff, GM Aldridge, JC Geerling

    Brain Structure and Function 227 (6), 1921-1932

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  • Neuropeptide S (NPS) neurons: Parabrachial identity and novel distributions

    Dake Huang, Richie Zhang, Silvia Gasparini, Miriam C. McDonough, William J. Paradee, JC Geerling

    Journal of Comparative Neurology 530 (18), 3157-3178

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  • Pre-locus coeruleus neurons in rat and mouse

    S Gasparini, JM Resch, AM Gore, L Peltekian, JC Geerling

    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

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  • Kölliker–Fuse GABAergic and glutamatergic neurons project to distinct targets

    JC Geerling, Shigefumi Yokota, Irma Rukhadze, Dan Roe, Nancy L Chamberlin

    Journal of Comparative Neurology 525 (8), 1844-1860

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Sodium Appetite

  • Aldosterone-induced salt appetite requires HSD2 neurons

    Silvia Gasparini, Lila Peltekian, Miriam C. McDonough, Chidera J.A. Mitchell, Marco Hefti, Jon M. Resch, JC Geerling

    JCI insight 9 (23), e175087

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  • Sodium appetite and thirst do not require angiotensinogen production in astrocytes or hepatocytes

    L Peltekian, S Gasparini, FS Fazan, S Karthik, G Iverson, JM Resch, JC Geerling

    The Journal of physiology 601 (16), 3499-3532

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  • Aldosterone-sensitive HSD2 neurons in mice

    Silvia Gasparini, Jon M Resch, Sowmya V Narayan, Lila Peltekian, Gabrielle N Iverson, Samyukta Karthik, JC Geerling

    Brain Structure and Function

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  • Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin Il Signaling

    Jon M Resch, Henning Fenselau, Joseph C Madara, Chen Wu, John N Campbell, Anna Lyubetskaya, Brian A Dawes, Linus T Tsai, Monica M Li, Yoav Livneh, Qingen Ke, Peter M Kang, Géza Fejes-Tóth, Anikó Náray-Fejes-Tóth, JC Geerling, Bradford B Lowell

    Neuron 96 (1), 190-206. e7

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  • Central regulation of sodium appetite

    JC Geerling, AD Loewy

    Experimental physiology 93 (2), 177-209

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  • Aldosterone in the brain

    JC Geerling, AD Loewy

    American Journal of Physiology-Renal Physiology 297 (3), F559-F576

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  • Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite

    JC Geerling, WC Engeland, M Kawata, AD Loewy

    Journal of Neuroscience 26 (2), 411-417

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  • Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment

    JC Geerling, AD Loewy

    Brain research 1115 (1), 54-64

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  • Aldosterone‐sensitive neurons in the nucleus of the solitary tract: Efferent projections

    JC Geerling, AD Loewy

    Journal of Comparative Neurology 497 (2), 223-250

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  • Aldosterone‐sensitive neurons in the rat central nervous system

    JC Geerling, M Kawata, AD Loewy

    Journal of Comparative Neurology 494 (3), 515-527

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  • Aldosterone infusion into the 4th ventricle produces sodium appetite with baroreflex attenuation independent of renal or blood pressure changes

    S Gasparini, MR Melo, GMF Andrade-Franze, JC Geerling, JV Menani, E. Colombari

    Brain research 1698, 70-80

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  • Despite increasing aldosterone, elevated potassium is not necessary for activating aldosterone‐sensitive HSD2 neurons or sodium appetite

    FS Fazan, E Colombari, AD Loewy, JC Geerling

    Physiological reports 9 (2), e14714

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  • Sodium deprivation and salt intake activate separate neuronal subpopulations in the nucleus of the solitary tract and the parabrachial complex

    JC Geerling, AD Loewy

    Journal of Comparative Neurology 504 (4), 379-403

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  • FoxP2 expression defines dorsolateral pontine neurons activated by sodium deprivation

    JC Geerling, MK Stein, RL Miller, JW Shin, PA Gray, AD Loewy

    Brain research 1375, 19-27

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  • Vagal innervation of the aldosterone-sensitive HSD2 neurons in the NTS

    JW Shin, JC Geerling, AD Loewy

    Brain research 1249, 135-147

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  • Phox2b expression in the aldosterone-sensitive HSD2 neurons of the NTS

    JC Geerling, PC Chimenti, AD Loewy

    Brain research 1226, 82-88

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Interoception

  • Molecular Ontology of the Nucleus of Solitary Tract

    Silvia Gasparini, Gislaine Almeida-Pereira, Ana Sofia Peraza Munuzuri, Jon M. Resch, JC Geerling

    Journal of Comparative Neurology 530 (10), 1658-1699

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  • Central afferents to the nucleus of the solitary tract in rats and mice

    Silvia Gasparini, Jacob M Howland, Andrew J Thatcher, JC Geerling

    Journal of Comparative Neurology 528 (16), 2708-2728

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  • Sodium depletion activates the aldosterone-sensitive neurons in the NTS independently of thirst

    JC Geerling, AD Loewy

    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology Vol. 292, No. 3

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  • Aldosterone-Sensitive Neurons in the Nucleus of the Solitary Tract: Bidirectional Connections With the Central Nucleus of the Amygdala

    JC Geerling, AD Loewy*

    Journal of Comparative Neurology 497 (4), 646-657

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  • Molecular ontology of the parabrachial nucleus

    Samyukta Karthik, Dake Huang, Yaritza Delgado, Justin J. Laing, Lila Peltekian, Gabrielle N. Iverson, Fillan Grady, Rebecca L. Miller, Corey M. McCann, Bernd Fritzsch, Igor Y. Iskusnykh, Victor V. Chizhikov, JC Geerling

    Journal of Comparative Neurology 530 (10), 1658-1699

    Full Text

  • Aldosterone‐sensitive neurons in the nucleus of the solitary tract: Efferent projections

    JC Geerling, AD Loewy

    Journal of Comparative Neurology 497 (2), 223-250

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  • Vagal innervation of the aldosterone-sensitive HSD2 neurons in the NTS

    JW Shin, JC Geerling, AD Loewy

    Brain research 1249, 135-147

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  • Sustained, Effortless Weight Loss after Damage to the Left Frontoinsular Cortex: A Case Report

    BD Reasoner, AD Boes, JC Geerling

    Case reports in neurology 15 (1), 63-68

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Consciousness

  • A century searching for the neurons necessary for wakefulness

    FS Grady, AD Boes, JC Geerling

    Frontiers in neuroscience 16, 930514

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  • Parabrachial-insular stimulation does not wake mice

    FS Grady, SA Graff, JM Resch, JC Geerling

    Journal of neurophysiology 129 (2), 347-355

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  • Thalamic strokes that severely impair arousal extend into the brainstem

    J Hindman, MD Bowren, J Bruss, B Wright, JC Geerling, AD Boes

    Annals of neurology 84 (6), 926-930

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  • A human brain network derived from coma-causing brainstem lesions

    David B. Fischer, Aaron D. Boes, Athena Demertzi, Henry C. Evrard, Steven Laureys, Brian L. Edlow, Hesheng Liu, Clifford B. Saper, Alvaro Pascual-Leone, Michael D. Fox, JC Geerling

    December 6, 2016 issue 87 (23) 2427-2434

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  • Connectivity of sleep-and wake-promoting regions of the human hypothalamus observed during resting wakefulness

    AD Boes, D Fischer, JC Geerling, J Bruss, CB Saper, MD Fox

    Sleep 41 (9), zsy108

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Autonomic Control & Continence

  • Barrington's nucleus: Neuroanatomic landscape of the mouse “pontine micturition center”

    AMJ Verstegen, V Vanderhorst, PA Gray, ML Zeidel, JC Geerling

    Journal of Comparative Neurology 525 (10), 2287-2309

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  • Non-Crh glutamatergic neurons in Barrington’s nucleus control micturition via glutamatergic afferents from the midbrain and hypothalamus

    Anne M J Verstegen, Nataliya Klymko, Lin Zhu, John C Mathai, Reina Kobayashi, Anne Venner, Rachel A Ross, Veronique G VanderHorst, Elda Arrigoni, JC Geerling, Mark L Zeidel

    Current Biology 29 (17), 2775-2789. e7

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  • The brain and the bladder: forebrain control of urinary (in) continence

    MM Tish, JC Geerling

    Frontiers in Physiology 11, 658

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  • Micturition video thermography in awake, behaving mice

    AM Verstegen, MM Tish, LP Szczepanik, ML Zeidel, JC Geerling

    Journal of neuroscience methods 331, 108449

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  • Normal pressure hydrocephalus in adult mice causes gait impairment, cognitive deficits, and urinary frequency with incontinence

    Margaret M. Tish, Natalie A. Voss, Aimee X. Bertolli, Miles J. Klimara, Richard J. Smith, Daniel R. Thedens, Chantal Allamargot, Marco M. Hefti, Matthew A. Howard, Georgina M. Aldridge, JC Geerling

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  • Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus

    JC Geerling, Bradford B. Lowell, Thomas E. Scammell, et al.

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  • Paraventricular Hypothalamic Nucleus: Axonal Projections to the Brainstem

    JC Geerling, Jung-Won Shin, Peter C. Chimenti, Ad Loewy*

    Journal of Comparative Neurology 518 (9), 1460-1499

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  • Orexin neurons project to diverse sympathetic outflow systems

    JC Geerling, TC Mettenleiter, AD Loewy

    Neuroscience 122 (2), 541-550

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Clinical Translation

  • Sustained, Effortless Weight Loss after Damage to the Left Frontoinsular Cortex: A Case Report

    BD Reasoner, AD Boes, JC Geerling

    Case reports in neurology 15 (1), 63-68

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  • Normal pressure hydrocephalus in adult mice causes gait impairment, cognitive deficits, and urinary frequency with incontinence

    Margaret M. Tish, Natalie A. Voss, Aimee X. Bertolli, Miles J. Klimara, Richard J. Smith, Daniel R. Thedens, Chantal Allamargot, Marco M. Hefti, Matthew A. Howard, Georgina M. Aldridge, JC Geerling

    Eneuro 11 (11)

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  • Right tegmental hemorrhage with urinary retention: a case report

    MM Tish, AD Boes, JC Geerling

    Case reports in neurology 14 (1), 68-71

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  • A 63-year-old man with rapidly progressive dementia

    A Hale, JC Geerling, D Schmolze, R Pfannl, AW Karchmer

    Clinical Infectious Diseases 63 (1), 138-139

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  • Urinary sodium excretion measures and health outcomes

    DA McCarron, JC Geerling, MH Alderman

    The Lancet 393 (10178), 1294-1295

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  • Normal range of human dietary sodium intake: a perspective based on 24-hour urinary sodium excretion worldwide

    DA McCarron, AG Kazaks, JC Geerling, JS Stern, NA Graudal

    American Journal of Hypertension 26 (10), 1218-1223

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  • Can Dietary Sodium Intake Be Modified by Public Policy?

    DA McCarron, JC Geerling, AG Kazaks, JS Stern

    Clinical Journal of the American Society of Nephrology 4 (11), 1878-1882

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